Cell Damage and Adaptation

Cellular adaptation attribute to changes made by a cell in response to adverse or varying environmental changes. The adaptation may be physiological or pathological. There are two types of patterns displayed by an injured cell: 1) Reversible cell injury that leads to cellular adaptation, 2) Irreversible cell injury that leads to cell death and tissue damage. When cells adapt to injury, their adaptive changes can be any of the five types:  atrophy, hypertrophy, hyperplasia, dysplasia, or metaplasia and they may also accumulate fat, cholesterol, protein, glycogen, or pigment. When cells are irreversibly injured or dying, specific nuclear changes may be seen such as pyknosis, karyorrhexis, and karyolysis. If large numbers of cells die, tissue may follow necrosis.

  • Biochemical Mechanisms of Cell Damage
  • Reperfusion Damage
  • Cellular Adaptation to Injury
  • Coagulative Necrosis and Apoptosis

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